Safety Data Sheet for Cellulose microcrystalline 102331. stream ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM No. . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. These, in turn, are assembled into fibrils in the cell wall. 0.25 - 0.37. Date Approved: 05/25/2010. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. X\o^ Magazine: Material safety data sheet - FMC Corporation. There have always been two different points of view for the liquidity of MCC. pH 6.0 to 8.0 . 2008-2023 ChemPoint. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. 51395-75-6 Avicel RC 591. q9;v80 CoA. Truly distinctive drug delivery solutions. Regulatory Information FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC SDS - Safety Data Sheet. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . : 5. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. The table below shows the most common physicochemical parameters of this raw material. PDF (4.11 mb) Footer menu 1. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. The cellulose molecule is formed through repeated condensation of cellobiose units. EMCOCEL 90 M. 130. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. A family of polysaccharide products that allow distinctive drug delivery solutions. Quantity: 1 700 kgs. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. A., and Smith, P. A. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. % endobj Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. endobj It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. endstream A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. CAS 9004-34-6, pH 5 - 7.5. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Eur., JPE . Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. An agricultural sciences company. stream In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. : 160182. Report Category. Superior Performance: Provides excellent water uptake and rapid swelling . Avicel PC 611 (FMC Biopolymer) Supplied by. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. We are artists at heart and creators by nature. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. : 9004-34-6 Date Approved: 01/31/2008 . Doses up to 30 g per day appear to be . (Microcrystalline Cellulose Market Pr. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Explore how we work and why we apply science and creativity for a better world to everything we do. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" MCC helps in the formation of spheres because of its . Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. stream AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . SUBSTANCE IDENTIFICATION 1.1. It is also inert and biocompatible. CAS No. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. CAS #: 9004-34-6 By producing Avicel . /Contents 4 0 R Molecular weight: Not Applicable 1.5. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Microcrystalline Cellulose / Avicel PH-102. 3 0 obj Avicel RC-591 & CL-611 - Description. Microcrystalline Cellulose (MCC) Manufacturing Industry. The data shown below apply only to Avicel PH 101. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Avicel Microcrystalline Cellulose Physical Properties. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. /Type/Page CAS #: 9004-34-6 . << In extrusion-spheronisation, it is the excipient of choice. SDS. 1 0 obj FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. 6 0 obj Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Packaging: 34 x 50 kgs fiber drums. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) The most. LOT #: Available upon request. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. . gac74 [#B6`Wnw7 To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Cellulose microcrystalline for column chromatography. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication 9,LL!z Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. <> HMo@9, U Q!R/1*;` Avicel PC 611 (FMC Biopolymer) . IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. All Rights Reserved. If you are already a ChemPoint customer then sign up for access to our online ordering website. Product Name Cellulose microcrystalline. >> The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. If breathing is difficult or if . The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Watch Now. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Combines good flow and high compactibility. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. All rights reserved. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Microcrystalline Cellulose NF. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Page 1 of 8. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. cas:9032-51-3 msds CELLULOSE PAB. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. xv}O2' H~KEe9>G/,:9\i X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. >> However, consumption of large quantities of the material may have a laxative effect. }o]X4]. stream FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Revision No. Fiber supplements can lessen the absorption of some . The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed.